Serotonin receptors of the 5-HT3 type are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. Plasma protein binding of ondansetron as measured in vitro was 70 to 76 with binding constant over the pharmacologic concentration range 10 to 500 ng mL. Use in Surgical Patients: The coadministration of ondansetron had no effect on the pharmacokinetics and pharmacodynamics of temazepam. Tell your doctor immediately if any of these unlikely but serious side effects occur: stomach pain, muscle spasm stiffness, vision changes. These patients were receiving multiple concomitant perioperative and postoperative medications. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Previous next Report Problems to the purchase generic zofran online Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA.