Intensive clinical and laboratory monitoring, including liver viramune online kob enzymes, is essential during the first 18 weeks of therapy with VIRAMUNE to detect potentially life- threatening hepatotoxicity and skin reactions. Gender In the multinational 2NN study, population pharmacokinetic substudy of 1077 patients was performed that included 391 females. Nevirapine belongs to class of drugs known as non-nucleoside reverse transcriptase inhibitors. Using single-dose Viramune at the time of delivery, provided that other anti-HIV medications have been used during pregnancy and will continue to be used after the baby is born is possible. The second major study presented, BI 1046, an international randomized, double blind, placebo-controlled trial, investigated viramune in previously untreated subjects. The Antiretroviral Pregnancy Registry, which has been surveying pregnancy outcomes since January 1989, has not found an increased risk of birth defects following first trimester exposures to nevirapine.