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Valacyclovir passes into breast milk and may harm nursing infant. Take valacyclovir order valacyclovir usa by mouth, as directed by your doctor, with or without food. No significant difference was observed between subjects receiving VALTREX or placebo in the prevention of progression of cold sore lesions beyond the papular stage. If you wait more than 72 hours after you first get herpes zoster rash, the medication may not be effective.