It anti-inflammatory properties reduces the inflammation and swelling of the sebaceous glands seen in acne. Excretion of the drug is slow and constant blood level can be maintained with the usual dosage. 219,220,221,224,225 Therapeutic alternatives in cases in which dapsone is not well tolerated, or its effects are insufficient or transient, include systemic or topical steroids, dapsone aus indien PUVA, retinoids and various combinations of these. In this series, the long-term outcome after brown recluse spider bite was good compared to other reported series. Under WHO, daily Rifampin may be replaced by 600 mg Rifampin monthly, if supervised. Cutaneous reactions, especially bullous, include exfoliative dermatitis and are probably one of the most serious, though rare, complications of sulfone therapy. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.