Stanek, PharmD, senior director of research, personalized medicine research and development, Medco Health Solutions, Franklin Lakes, NJ, and the study principal investigator. Gender No significant difference was observed in the plasma levels of the main circulating metabolite between males and females. The main circulating metabolite is the carboxylic acid derivative, and it too has no effect on platelet aggregation. Clopidogrel was found to have no effect on fertility of male and female rats at oral doses up to 400 mg kg per day 52 times the recommended human dose on mg m2 basis. PPIs are also frequently prescribed to these patients for brief periods approximately 30 days following stent insertion to treat unpleasant but non-life-threatening side effects of clopidogrel such as nausea. Link to Page Print Page Email Page Add to List More Clopidogrel resources clopidogrel effekter Plavix Plavix Clopidogrel Clopidogrel Includes detailed dosage instructions. However, in clinical trials the benefit of clopidogrel and aspirin in patients with ACS with or without ST-segment-elevation outweighed the risk of major bleeding.